Written in English
Thesis (Ph.D.) - Loughborough University of Technology, 1992.
|Statement||by Michael J. Hewitt.|
The model we propose is composed of five stages: the outer and middle ear, the basilar membrane, the inner hair cells, the auditory nerve fibers, the cochlear nucleus and the inferior colliculus. The outer and middle ear filtering consists in four second order Butterworth filters in by: 3. A computer model of a ventral-cochlear-nucleus (VCN) stellate cell with chop-S type response properties is presented and evaluated. The model is based on a simplified model of. A computer model of dorsal cochlear nucleus pyramidal cells: Intrinsic membrane properties Article (PDF Available) in The Journal of the Acoustical Society of America 97(4) May There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I auditory nerve fibers. Here we review a comprehensive series of experiments aimed at determining how loss of the IHC/type I system affects hearing by selectively destroying these cells in chinchillas using the.
The use of stem cells, exogenous or endogenous, provides the potential to treat deafness by replacing lost hair cells or lost auditory nerve. Embryonic stem cells or stem cells derived from bone marrow can be induced to reach a hair cell-like phenotype [–] or an auditory . Hair Cells, Auditory Hair Hair Cells, Auditory, Inner Hair Cells, Auditory, Outer Hair Cells, Vestibular Saccule and Utricle Cochlea Organ of Corti Hair Follicle Ear, Inner Stereocilia Hair Cells, Ampulla Lateral Line System Spiral Ganglion Acoustic Maculae Vestibule, Labyrinth Cochlear Nerve Stria Vascularis Basilar Membrane Tectorial Membrane. Brain Stem Auditory Pathways Cochlear Nucleus Cochlea Cochlear Nerve Olivary Nucleus Spiral Ganglion Inferior Colliculi Stapedius Hair Cells, Auditory, Inner Hair Cells, Auditory Neurons Stria Vascularis Round Window, Ear Hair Cells, Auditory, Outer Organ of Corti Cochlear Duct Auditory Cortex Ear, Middle Ear, Inner Synapses Tympanic Membrane. -There are fewer inner hair cells than outer hair cells -Outer hair cells are closer to the spiral ligament than inner hair cells. The cochlear nucleus on the right side receives ipsilateral information only 6. neurotransmitter release at base of hair cells 7. activation of auditory nerve fibers in contact with the hair cells.
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 35) () An evaluation of eight computer models of mammalian inner hair-cell function. J Acoust Soc Am – PubMed CrossRef () A computer model of a cochlear-nucleus stellate cell: responses to amplitude-modulated and pure-tone stimuli. A computer model is presented of a neural circuit that replicates amplitude-modulation (AM) sensitivity of cells in the central nucleus of the inferior colliculus (ICC}. The ICC cell is modeled as a point neuron whose input consists of spike trains from a number of simulated ventral cochlear nucleus (VCN) chopper cells. Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical impulses that subserve audition 1, of hair cells and their innervating neurons is the most frequent cause of hearing impairment homolog 1 (Atoh1, also known as Math1) is a basic helix-loop-helix transcription factor required for hair cell development and its misexpression in vitro 7, 8. A computer model of the auditory periphery is used to study the involvement of auditory-nerve (AN) adaptation in forward-masking effects. An existing model is shown to simulate published AN recovery functions both qualitatively and quantitatively after appropriate parameter adjustments. It also simulates published data showing only small threshold shifts when a .